PUTATIVE EARLY RISK FACTORS AT BONE-IMPLANT INTERFACE IN IMMEDIATE LOADING

during osseointegration a dental implant early develops special spatial and molecular relationships wit surrounding tissues. The surface roughness and microtopography are closely related to a long-term clinical success. A better understanding of various but relevant molecules, and even of genes, that encodes biological factors involved in tissue healing should be considered useful in particular cases. Biocompatibility of implant is not yet considered as a solved problem, at infrastructural and molecular level, at least on long-term. Various biological factors, already in use, such as platelet-rich plasma, and growth factors, should be under control in order to follow a more efficient pathway towards a reliable osseointegration. A paramount attention has to be done, on long-term, to the functional modulation of bone tissue-dental implant, especially in immediate occlusal loading of dental implants.