THE IMPACT OF DEXAMETHASONE ON HEARING-LOSS IN EXPERIMENTAL PNEUMOCOCCAL MENINGITIS

被引：34

作者：

BHATT, SM

CABELLOS, C

NADOL, JB

HALPIN, C

LAURETANO, A

XU, WZ

TUOMANEN, E

机构：

[1] ROCKEFELLER UNIV,MOLEC INFECT DIS LAB,NEW YORK,NY 10021

[2] MASSACHUSETTS EYE & EAR INFIRM,BOSTON,MA 02114

[3] HARVARD UNIV,SCH MED,DEPT OTOL & LARYNGOL,BOSTON,MA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 1995年 / 14卷 / 02期

关键词：

MENINGITIS; HEARING LOSS; DEXAMETHASONE; STREPTOCOCCUS PNEUMONIAE;

D O I：

10.1097/00006454-199502000-00002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacterial meningitis, particularly that resulting from Streptococcus pneumoniae, is a common cause of acquired profound sensorineural deafness in children. The pathogenesis of meningogenic hearing loss has been investigated in an experimental rabbit model. In this study significant deafness was documented within the first 15 hours of infection. Initiation of antibiotic therapy at this time diminished the severity of hearing loss in most animals. The addition of dexamethasone to antibiotic therapy prevented the development of profound deafness. These results suggest this model will be useful in developing antiinflammatory strategies to improve the outcome of bacterial meningitis.

引用

页码：93 / 96

页数：4

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