ASSIGNMENT OF THE HUMAN CYTOCHROME-P-450 NIFEDIPINE OXIDASE GENE (CYP3A4) TO CHROMOSOME-7 AT BAND Q22.1 BY FLUORESCENCE INSITU HYBRIDIZATION

被引：49
|
作者：
INOUE, K
INAZAWA, J
NAKAGAWA, H
SHIMADA, T
YAMAZAKI, H
GUENGERICH, FP
ABE, T
机构：
[1] KYOTO PREFECTURAL UNIV MED,DEPT HYG,KYOTO 602,JAPAN
[2] KYOTO PREFECTURAL UNIV MED,DEPT MED,KYOTO 602,JAPAN
[3] VANDERBILT UNIV,MED CTR,SCH MED,CTR MOLEC TOXICOL,NASHVILLE,TN 37232
[4] VANDERBILT UNIV,MED CTR,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232
来源：
JAPANESE JOURNAL OF HUMAN GENETICS | 1992年 / 37卷 / 02期
关键词：
FLUORESCENCE INSITU HYBRIDIZATION; CYP3A4; CHROMOSOMAL MAPPING; CHROMOSOME-7;
D O I：
10.1007/BF01899734
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We have used a full length cDNA clone (2.2 kb) for the human cytochrome P-450 nifedipine oxidase (CYP3A4) enzyme as a probe to determine its chromosome localization by fluorescence in situ hybridization. CYP3A4 was mapped on R-banded human prometaphase chromosomes, and the precise localization of CYP3A4 on chromosome 7 was further confirmed by a delineation of G-banded pattern on the same prometaphase chromosomes through a combination of UV-filter. We assigned CYP3A4 to chromosome 7 at q22.1.
引用
收藏
页码：133 / 138
页数：6
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