NEW ELEMENTS OF GLUCOCORTICOID-RECEPTOR BINDING-SITES OF HORMONE-REGULATED GENES

被引：7

作者：

SELEDTSOV, IA ^{[1
]}

SOLOVYEV, VV ^{[1
]}

MERKULOVA, TI ^{[1
]}

机构：

[1] ACAD SCI USSR, INST CYTOL & GENET, DEPT MOLEC GENET, NOVOSIBIRSK 630090, USSR

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1089卷 / 03期

关键词：

GLUCOCORTICOID-RECEPTOR COMPLEX; DNA ACCEPTOR SITE; MAMMARY-TUMOR VIRUS; ALPHA-FETOPROTEIN GENE; PHOSPHOENOLPYRUVATE CARBOXYKINASE GENE; RAT ALPHA-1-ACID GLYCOPROTEIN; PRO-OPIOMELANOCORTIN GENE; METALLOTHIONEIN-II GENES; HUMAN INSULIN GENE; TRANSCRIPTIONAL REGULATION; ALCOHOL-DEHYDROGENASE; RESPONSIVE ELEMENTS;

D O I：

10.1016/0167-4781(91)90178-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the DNA regions recognized by glucocorticoid-receptor complexes (GIRC) was analyzed using frequency matrices and a modified perceptron method. Some complementary conservative elements which may modulate the efficiency of GIRC binding were found at both sides of the previously established conserved nucleotide sequence (core) (Beato, M. et al. (1987) J. Steroid Biochem. 27, 9-14). A criterion based on the concurrent use of several perceptron matrices to search for the potential GIRC binding site sequences has been worked out. By applying this criterion 73 sites were identified in 28 sequences of glucocorticoid regulated genes and 7 sites were identified in 26 sequences independent from glucocorticoid regulation.

引用

页码：367 / 376

页数：10

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