Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon

被引：5

作者：

Hammond, William A. ^{[1
]}

Crozier, Jennifer A. ^{[1
]}

Nakhleh, Raouf E. ^{[2
]}

Mody, Kabir ^{[1
]}

机构：

[1] Mayo Clin, Ctr Canc, Dept Hematol Oncol, 4500 San Pablo Rd, Jacksonville, FL 32224 USA

[2] Mayo Clin, Dept Pathol, Jacksonville, FL 32224 USA

来源：

JOURNAL OF GASTROINTESTINAL ONCOLOGY | 2016年 / 7卷 / 02期

关键词：

Colon cancer; genomic profiling; neuroendocrine carcinoma;

D O I：

10.3978/j.issn.2078-6891.2015.090

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High-grade neuroendocrine carcinoma (HGNEC) of the colon is a rare and aggressive cancer that has a poor prognosis. Currently no standard treatment exists, and published case series report an overall survival of approximately one year with treatment. Typically patients receive treatment similar to that recommended for small-cell lung cancer, extrapolating from the similarity in cancer biology. Here we report a case of HGNEC of the colon with genomic profiling that identified a KRAS G12D mutation and a PI3K mutation that has not yet been reported in the literature for this tumor type.

引用

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页码：E22 / E24

页数：3

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