STEREOCONTROLLED CONVERGENT SYNTHESIS OF HYDROXYETHYLENE DIPEPTIDE ISOSTERES BY THE REACTION OF ALPHA-AMINO ALDEHYDE WITH ALKOXYTITANIUM HOMOENOLATES

被引：33
|
作者：
KANO, S [1 ]
YOKOMATSU, T [1 ]
SHIBUYA, S [1 ]
机构：
[1] TOKYO COLL PHARM,1432-1 HORINOUCHI,HACHIOJI,TOKYO 19203,JAPAN
来源：
TETRAHEDRON LETTERS | 1991年 / 32卷 / 02期
关键词：
D O I：
10.1016/0040-4039(91)80863-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of (S)-alpha-dibenzylamino aldehydes with dichloroisopropoxy-titanium ester homoenolates gave the corresponding gamma-aminoalkyl gamma-lactones with high erythro selectivity. The same reaction by the use of amide homoenolates also afforded the corresponding 2-amino alcohols with high erythro-selectivity.
引用
收藏
页码：233 / 236
页数：4
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