TUMOR-INHIBITING [1,2-BIS(DIFLUOROPHENYL)ETHYLENEDIAMINE]-DICHLOROPLATINUM(II) COMPLEXES .1. SYNTHESIS

被引：3

作者：

MULLER, R ^{[1
]}

SCHICKANEDER, E ^{[1
]}

JENNERWEIN, M ^{[1
]}

REILE, H ^{[1
]}

SPRUSS, T ^{[1
]}

ENGEL, J ^{[1
]}

SCHONENBERGER, H ^{[1
]}

机构：

[1] ASTA PHARMA AG,W-6000 FRANKFURT 1,GERMANY

来源：

ARCHIV DER PHARMAZIE | 1991年 / 324卷 / 02期

关键词：

D O I：

10.1002/ardp.19913240211

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of the diastereomeric 1,2-bis(2,3-, 2,4-, 2,5-, 2,6-, 3,4-, 3,5-difluorophenyl)ethylenediamines (meso, D/L 8-13) from meso 1,2-bis(2-hydroxyphenyl)ethylenediamine and the respective difluorobenzaldehyde by a diaza-Cope-rearrangement and their conversion into the [1,2-bis(2,3-, 2,4-, 2,5-, 2,6-, 3,4-, 3,5-difluorophenyl)ethylenediamine]dihaloplatinum(II)-complexes (meso, D/L 8-13 PtCl2; meso D/L 9- and 11-PtI2) with K2PtHal4 (Hal = Cl, I) is described. From the diiodoplatinum(II)-complexes (meso D/L 9- and 11-PtI2) the better water soluble diaqua[1,2-bis(2,4- and 2,6-diffluorophenyl)ethylenediamine]platinum(II) sulfates (meso, D/L 9- and 11-PtSO4) are obtained by reaction with Ag2SO4.

引用

页码：115 / 120

页数：6

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