HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF IMIDAZOLIUM AND PYRIDINIUM OXIMES IN PLASMA AND URINE

被引：4
|
作者：
SHIH, ML
SMITH, JR
SALEM, GW
机构：
[1] U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 527卷 / 02期
关键词：
D O I：
10.1016/S0378-4347(00)82120-9
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Imidazolium oximes are useful in the treatment of organophosphorus agent poisoning. However, the extant methods for analyzing oximes in plasma and urine samples are not adequate. A unique high-performance liquid chromatographic assay method was developed for quantitating either imidazolium or pyridinium oximes. Plasma or urine samples can be injected directly onto the column after a centrifugation filtration step. This method demonstrates a different approach in the method development for quaternary ammonium compounds using non-end-capped reversed-phase columns and a mobile phase containing competing cations. In addition, a preliminary pharmacokinetic study of the imidazolium oxime in rabbits was carried out using this method. © 1990.
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页码：371 / 379
页数：9
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