AMPLIFICATION OF HUMAN APO(A) KRINGLE 4-37 FROM BLOOD LYMPHOCYTE DNA

被引：12

作者：

PFAFFINGER, D

MCLEAN, J

SCANU, AM

机构：

[1] UNIV CHICAGO,DEPT MED,CHICAGO,IL 60637

[2] UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL,CHICAGO,IL 60637

[3] UNIV CHICAGO,COMM GENET,CHICAGO,IL

[4] NOVOGENICS,REDWOOD CITY,CA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1225卷 / 01期

关键词：

APOLIPOPROTEIN(A); KRINGLE; 4-37; LYSINE BINDING POCKET; PCR;

D O I：

10.1016/0925-4439(93)90130-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have been able to amplify the lysine binding pocket region of human apo(a) kringle type 5 starting from the DNA isolated from peripheral blood lymphocytes. This development now permits the identification of Lp(a) mutants that by lacking their ability to bind to lysine/fibrin would have a lesser thrombogenic potential.

引用

页码：107 / 109

页数：3

共 50 条

[1] AMPLIFICATION OF HUMAN APO(A) KRINGLE-4-37 FROM BLOOD LYMPHOCYTE DNA (VOL 1225, PG 107, 1993)
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