IMPORTANCE OF INTERLEUKIN-3 ON HISTAMINE-RELEASE FROM HUMAN BASOPHILS

被引：0
|
作者：
SUGIYAMA, H [1 ]
EDA, R [1 ]
HOPP, RJ [1 ]
BEWTRA, AK [1 ]
TOWNLEY, RG [1 ]
机构：
[1] CREIGHTON UNIV,SCH MED,CTR ALLERG DIS,2500 CALIF ST,OMAHA,NE 68178
来源：
ANNALS OF ALLERGY | 1993年 / 71卷 / 04期
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D O I：
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中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P < .0001).
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页码：391 / 395
页数：5
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