GENOMIC CLONING OF THE HUMAN HISTO-BLOOD GROUP ABO LOCUS

被引：105
|
作者：
BENNETT, EP
STEFFENSEN, R
CLAUSEN, H
WEGHUIS, DO
VANKESSEL, AG
机构：
[1] UNIV COPENHAGEN, FAC HLTH SCI, SCH DENT, DK-2200 COPENHAGEN N, DENMARK
[2] AALBORG BLOOD BANK, AALBORG, DENMARK
[3] UNIV NIJMEGEN HOSP, DEPT HUMAN GENET, 6500 HB NIJMEGEN, NETHERLANDS
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 206卷 / 01期
关键词：
D O I：
10.1006/bbrc.1995.1044
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A P1 phage clone containing the near complete protein coding region of the human histo-blood group ABO gene locus was isolated and characterized. The insert was estimated at approximate to 41 kp, and an approximate to 20 kbp BamHI fragment contained the near complete coding region as evaluated by Southern blot analysis. Intron/exon boundaries were determined and the coding region was found to span at least seven exons. In situ hybridization to metaphase chromosomes confirmed the predicted localization to 9q42. (C) 1995 Academic Press, Inc.
引用
收藏
页码：318 / 325
页数：8
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