ROLE OF PROTEASE INHIBITION IN MYOCARDIAL PRESERVATION FOLLOWING ISCHEMIA AND REPERFUSION

被引：0

作者：

GUREVITCH, J ^{[1
]}

PAZ, Y ^{[1
]}

BARAK, J ^{[1
]}

MATSA, M ^{[1
]}

KRAMER, A ^{[1
]}

PEVNI, D ^{[1
]}

HOCHHAUSER, E ^{[1
]}

YAKIREVICH, V ^{[1
]}

机构：

[1] ICHILOV HOSP,DEPT THORAC & CARDIOVASC SURG,IL-64239 TEL AVIV,ISRAEL

来源：

JOURNAL OF CARDIOVASCULAR SURGERY | 1994年 / 35卷 / 06期

关键词：

APROTININ; MYOCARDIAL REPERFUSION; ISCHEMIA;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aprotinin, a naturally occurring protease inhibitor, in concentrations of 10(6) KIU/L was found to have no effect on myocardial performance in normally perfused isolated rat hearts, before ischemia. Given during the preischemic period, the drug had a significant protective effect on the reperfused hearts, following cardioplegic ischemia: better contractility upon reperfusion (p < 0.011), faster decline of the ischemic contracture, higher coronary flow (p < 0,025), lower AV-difference (p < 0.05), and lower CPK levels (p < 0.01).

引用

页码：95 / 98

页数：4

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