10-CARBETHOXYMETHYL-3-PHENYL-1,2,4-TRIAZOLO[4',3'/2,3][1,2,4]TRIAZINO[5,6-B]INDOLE AND DERIVATIVES AT ITS 10-POSITION

被引：11

作者：

RASHED, N

ELNEMR, A

ELASHRY, EH

机构：

[1] Chemistry Department, Faculty of Science, Alexandria University, Alexandria

来源：

ARCHIV DER PHARMAZIE | 1993年 / 326卷 / 03期

关键词：

D O I：

10.1002/ardp.19933260307

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Reaction of 3-phenyl-10H-1,2,4-triazolo[4',3':2,3][1,2,4]triazino[5,6-b]indole (4) with ethyl chloroacetate gave 10-carbethoxymethyl-3-phenyl-1,2,4-triazolo[4',3':2,3][1,2,4]triazino[5,6-b]indole (3). Condensation of 3 with hydrazine hydrate gave (3-phenyl-1,2,4-triazolo[4',3':2,3][1,2,4]triazino[5,6-b]indol-10-yl)acetylhydrazine (5). Reactions of 5 with a number of aromatic aldehydes, acetophenone, cyclohexanone and D-galactose gave the corresponding hydrazones 6-12. Condensation of 5 with acetyl-acetone gave the pyrazole 15. Cyclization of 5 with CS2 gave (3-phenyl-1,2,4-triazolo[4',3':2,3][1,2,4]triazino[5,6-b]indol-10-yl)(2-thiol-1,3,4-oxadiazol-5-yl)methane (16). Reaction of 16 with ethyl chloroacetate gave the carbethoxy alkylated derivative (3-phenyl-1,2,4-triazolo[4',3':2,3][1,2,4]triazino[5,6-b]indol-10-yl)[2-(thiocarbethoxymethyl)1,3,4-oxadiazol-5-yl]methane (17).

引用

页码：153 / 156

页数：4

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