HEPATITIS-B VIRUS (HBV) GENOMIC VARIATIONS IN CHRONIC HEPATITIS

被引：0
|
作者：
CARIANI, E
FIORDALISI, G
PRIMI, D
机构：
来源：
ARCHIVES OF VIROLOGY | 1992年
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D O I：
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中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Using PCR we have examined the sequence of the pre-C/C region of HBV from sera of anti-HBe positive, chronically HBV-infected patients. The large majority of sera tested contained a mixture of heterogeneous pre-C sequences with 1-3 non-randomly located point mutations. Some of the resultant variant viruses are incapable of synthesizing immunogenic proteins and may be involved in viral persistence in chronic carrier states.
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页码：86 / 89
页数：4
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