A direct and non-invasive method for kidney delivery of therapeutics in mice

被引：2
|
作者：
Manaph, Nimshitha Pavathuparambil Abdul [1 ,2 ,3 ]
Al-Hawwas, Mohammed [1 ]
Zhou, Xin-Fu [1 ]
机构：
[1] Univ South Australia, Sch Pharm & Med Sci, Sansom Inst, Adelaide, SA 5000, Australia
[2] Royal Adelaide Hosp, Cent Northern Adelaide Renal & Transplantat Serv, Adelaide, SA 5000, Australia
[3] Univ Adelaide, Fac Hlth Sci, Sch Med, Adelaide, SA 5000, Australia
来源：
METHODSX | 2018年 / 5卷
关键词：
Kidney; Drugs; Delivery; Surgery; Injection;
D O I：
10.1016/j.mex.2018.10.019
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Kidney is a vital organ that maintains the homeostasis in terms of acid-balance, toxin filtration and blood pressure control. Kidney malfunction can be fatal and the renal research administers testing pharmaceutical agents or stem cells in rodents to study their therapeutic efficacy. However, targeted delivery of agents into mice kidney is strenuous and may require laparotomy. Here we present a direct delivery method for cell transplantation or drug injection into the mice kidney. The method is simple and can be performed non-invasively with avoidance of surgical intervention on the animals. Nevertheless, this method serves as an efficient method for in vivo drug delivery or engraftment studies for renal research. Direct delivery into the kidney. Non-invasive method. (C) 2018 The Authors. Published by Elsevier B.V.
引用
收藏
页码：1440 / 1446
页数：7
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