A NEW MODEL OF THE DEPRESSIVE SYNDROME INDUCED BY ADMINISTRATION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) IN RATS

被引：0
|
作者：
KRYZHANOVSKII, GN [1 ]
KRUPINA, NA [1 ]
KUCHERYANU, VG [1 ]
机构：
[1] RUSSIAN ACAD MED SCI, GEN PATHOL & PATHOPHYSIOL RES INST, GEN PATHOL NERVOUS SYST LAB, MOSCOW, RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1995年 / 119卷 / 02期
关键词：
MPTP; RATS; DEPRESSIVE SYNDROME; MODEL;
D O I：
10.1007/BF02445853
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Animals treated with MPTP neurotoxin displayed lowered motor and exploratory activity in the open field test, reduced daily intake of water with a preference for sugar solution over water, prolonged immobilization, and increased index of depression in the forced swimming test. The changes in rat behavior were preserved for at least a week after withdrawal of the drug. The data attest to the development of a state of lowered motivational activity combined with ahedony and ''behavioral despair'' in response to MPTP, making it possible to consider this state as a new experimental model of dopamine-dependent depressive syndrome in rats.
引用
收藏
页码：116 / 119
页数：4
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