A NEW MODEL OF THE DEPRESSIVE SYNDROME INDUCED BY ADMINISTRATION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) IN RATS

被引：0
|
作者：
KRYZHANOVSKII, GN [1 ]
KRUPINA, NA [1 ]
KUCHERYANU, VG [1 ]
机构：
[1] RUSSIAN ACAD MED SCI, GEN PATHOL & PATHOPHYSIOL RES INST, GEN PATHOL NERVOUS SYST LAB, MOSCOW, RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1995年 / 119卷 / 02期
关键词：
MPTP; RATS; DEPRESSIVE SYNDROME; MODEL;
D O I：
10.1007/BF02445853
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Animals treated with MPTP neurotoxin displayed lowered motor and exploratory activity in the open field test, reduced daily intake of water with a preference for sugar solution over water, prolonged immobilization, and increased index of depression in the forced swimming test. The changes in rat behavior were preserved for at least a week after withdrawal of the drug. The data attest to the development of a state of lowered motivational activity combined with ahedony and ''behavioral despair'' in response to MPTP, making it possible to consider this state as a new experimental model of dopamine-dependent depressive syndrome in rats.
引用
收藏
页码：116 / 119
页数：4
相关论文
共 50 条
  • [1] Effects of buspirone on experimental depressive syndrome induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in rats
    Krupina, NA
    Kryzhanovskii, GN
    Orlova, IN
    Iordanskaya, TE
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1996, 121 (05) : 444 - 448
  • [2] Effect of melipramine on the development of experimental depressive syndrome induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    Krupina, NA
    Orlova, IN
    Kryzhanovskii, GN
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1995, 120 (08) : 805 - 808
  • [3] REM sleep disorders in rats with experimental depressive syndrome caused by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    Krupina, NA
    Kryzhanovskii, GN
    Iordanskaya, TE
    Pankova, NB
    Orlova, IN
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1997, 123 (02) : 116 - 120
  • [4] REM sleep disorders in rats with experimental depressive syndrome caused by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    N. A. Krupina
    G. N. Kryzhanovskii
    T. E. Iordanskaya
    N. B. Pankova
    I. N. Orlova
    Bulletin of Experimental Biology and Medicine, 1997, 123 : 116 - 120
  • [5] DUODENAL-ULCER INDUCED BY MPTP (1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE)
    SZABO, S
    BROWN, A
    PIHAN, G
    DALI, H
    NEUMEYER, JL
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1985, 180 (03): : 567 - 571
  • [6] EXPERIMENTAL PARKINSONIAN SYNDROME INDUCED IN RATS BY 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
    KRYZHANOVSKII, AGN
    ATADZHANOV, MA
    ZAGOREVSKII, VA
    SHARKOVA, LM
    VORONINA, TA
    NEROBKOVA, LN
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1988, 105 (04) : 470 - 474
  • [7] Evidence of oligodendrogliosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism
    Annese, V.
    Barcia, C.
    Ros-Bernal, F.
    Gomez, A.
    Ros, C. M.
    De Pablos, V.
    Fernandez-Villalba, E.
    De Stefano, M. E.
    Herrero, M-T
    NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2013, 39 (02) : 132 - 143
  • [8] NEW AMPHIBIAN MODELS FOR THE STUDY OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)
    BARBEAU, A
    DALLAIRE, L
    BUU, NT
    VEILLEUX, F
    BOYER, H
    DELANNEY, LE
    IRWIN, I
    LANGSTON, EB
    LANGSTON, JW
    LIFE SCIENCES, 1985, 36 (11) : 1125 - 1134
  • [9] MPTP (1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE) A DOPAMINERGIC NEUROTOXIN IS A NEW DUODENAL ULCEROGEN IN RATS
    PIHAN, G
    MANGLA, J
    SZABO, S
    DIGESTIVE DISEASES AND SCIENCES, 1985, 30 (04) : 395 - 395
  • [10] STUDIES ON THE MECHANISM OF ACTION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)
    COHEN, G
    MYTILINEOU, C
    LIFE SCIENCES, 1985, 36 (03) : 237 - 242
12345