INTERLEUKIN-4-MEDIATED INDUCTION OF CD4+/CD8+ T-CELLS DURING INFANCY

被引：0
|
作者：
EBISAWA, M
REASON, DC
SAITO, H
NAKANO, S
SEO, K
KAWAMURA, K
IIKURA, Y
机构：
[1] CHILDRENS HOSP OAKLAND,RES INST,OAKLAND,CA
[2] FUJI CENT HOSP,DEPT PEDIAT,SHIZUOKA,JAPAN
[3] JIKEI UNIV,DEPT PEDIAT,TOKYO 105,JAPAN
来源：
ANNALS OF ALLERGY | 1991年 / 67卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Neonatal human CD4+ T cells will co-express CD8 on their surface following short-term culture with interleukin 4 (IL-4). Adult T cells do not respond in this manner. In this study we examine this phenomenon as a function of age and determine that IL-4 responsiveness decreases with time to approach adult levels at about 2 years. This phenomenon may be relevant to the documented ability of neonatal CD4+ T cells to function as suppressors.
引用
收藏
页码：612 / 614
页数：3
相关论文
共 50 条
  • [21] SPECIFIC EXPRESSION OF THE HUMAN CD4 GENE IN MATURE CD4+ CD8- AND IMMATURE CD4+ CD8+ T-CELLS AND IN MACROPHAGES OF TRANSGENIC MICE
    HANNA, Z
    SIMARD, C
    LAPERRIERE, A
    JOLICOEUR, P
    MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (02) : 1084 - 1094
  • [22] CD4+ AND CD8+ T-CELLS ACQUIRE SPECIFIC LYMPHOKINE SECRETION POTENTIALS DURING THYMIC MATURATION
    BENDELAC, A
    SCHWARTZ, RH
    NATURE, 1991, 353 (6339) : 68 - 71
  • [23] Metabolic Adaptation of Human CD4+ and CD8+ T-cells to T-cell Receptor-Mediated Stimulation
    Jones, Nicholas
    Cronin, James G.
    Dolton, Garry
    Panetti, Silvia
    Schauenburg, Andrea J.
    Galloway, Sarah A. E.
    Sewell, Andrew K.
    Cole, David K.
    Thornton, Catherine A.
    Francis, Nigel J.
    FRONTIERS IN IMMUNOLOGY, 2017, 8
  • [24] CLONAL ANALYSIS OF CD4+/CD8+ T-CELLS IN A PATIENT WITH APLASTIC-ANEMIA
    MOEBIUS, U
    HERRMANN, F
    HERCEND, T
    MEUER, SC
    JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (05): : 1567 - 1574
  • [25] RECOGNITION OF HUMAN PARAINFLUENZA TYPE-1 BY CD4+ AND CD8+ T-CELLS
    SLOBOD, KS
    ALLAN, JE
    PEDIATRIC RESEARCH, 1991, 29 (04) : A164 - A164
  • [26] DIFFERENTIAL HTLV-I REPLICATION IN CD4+ VERSUS CD8+ T-CELLS
    NEWBOUND, G
    RATNER, L
    LAIRMORE, M
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 1994, 10 (04) : 454 - 454
  • [27] 5-AZACYTIDINE INDUCES AUTOREACTIVITY IN POLYCLONAL CD4+ BUT NOT CD8+ T-CELLS
    RICHARDSON, B
    CLINICAL RESEARCH, 1988, 36 (03): : A446 - A446
  • [28] ROLE OF CD4+ AND CD8+ T-CELLS IN MURINE RESISTANCE TO STREET RABIES VIRUS
    PERRY, LL
    LODMELL, DL
    JOURNAL OF VIROLOGY, 1991, 65 (07) : 3429 - 3434
  • [29] Regulation of cytokine production by CD4+ and CD8+ T cells
    Corbin, GA
    Harty, JT
    FASEB JOURNAL, 2004, 18 (04): : A436 - A437
  • [30] CD4+ T Cells and Lactobacillus casei Control Relapsing Colitis Mediated by CD8+ T Cells
    Hacini-Rachinel, Feriel
    Nancey, Stephane
    Boschetti, Gilles
    Sardi, Fatima
    Doucet-Ladeveze, Remi
    Durand, Pierre-Yves
    Flourie, Bernard
    Kaiserlian, Dominique
    JOURNAL OF IMMUNOLOGY, 2009, 183 (09): : 5477 - 5486
12345