INTERLEUKIN-4-MEDIATED INDUCTION OF CD4+/CD8+ T-CELLS DURING INFANCY

被引：0
|
作者：
EBISAWA, M
REASON, DC
SAITO, H
NAKANO, S
SEO, K
KAWAMURA, K
IIKURA, Y
机构：
[1] CHILDRENS HOSP OAKLAND,RES INST,OAKLAND,CA
[2] FUJI CENT HOSP,DEPT PEDIAT,SHIZUOKA,JAPAN
[3] JIKEI UNIV,DEPT PEDIAT,TOKYO 105,JAPAN
来源：
ANNALS OF ALLERGY | 1991年 / 67卷 / 06期
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D O I：
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中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Neonatal human CD4+ T cells will co-express CD8 on their surface following short-term culture with interleukin 4 (IL-4). Adult T cells do not respond in this manner. In this study we examine this phenomenon as a function of age and determine that IL-4 responsiveness decreases with time to approach adult levels at about 2 years. This phenomenon may be relevant to the documented ability of neonatal CD4+ T cells to function as suppressors.
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页码：612 / 614
页数：3
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