SYNTHESIS OF 1,6-ANHYDRO-2,3-DI-O-FARNESYL-5-O-([(PHOSPHONOMETHYL)PHOSPHINYL]METHYL)-ALPHA-D-GALACTOFURANOSE - A ZARAGOZIC ACID - PRESQUALENE PYROPHOSPHATE HYBRID

被引：6

作者：

VALENTIJN, ARPM

BROXTERMAN, HJG

VANDERMAREL, GA

COHEN, LH

VANBOOM, JH

机构：

[1] LEIDEN UNIV,GORLAEUS LABS,LEIDEN INST CHEM,2300 RA LEIDEN,NETHERLANDS

[2] TNO PREVENT & HLTH,GAUBIUS LAB,2301 CE LEIDEN,NETHERLANDS

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1995年 / 14卷 / 06期

关键词：

D O I：

10.1080/07328309508005373

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A multi-step synthesis of a new potential inhibitor (i.e., compound 2) of squalene synthase is described, starting from D-galactose. The title compound is a hybrid of presqualene pyrophopshate and the recently discovered zaragozic acids, which are picomolar competitive inhibitors of the enzyme squalene synthase.

引用

页码：737 / 749

页数：13

共 48 条

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