Design and synthesis some analogs of propranolol using essential amino acid

被引：0

作者：

Baidya, M. ^{[1
]}

Das, A. K. ^{[1
]}

机构：

[1] Krupanidhi Coll Pharm, Dept Pharmaceut Chem, Bangalore 560035, Karnataka, India

来源：

ORIENTAL JOURNAL OF CHEMISTRY | 2009年 / 25卷 / 02期

关键词：

Antihypertensive; epichlorohydrine; Propranolol;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Propranolol is a non-selective beta blocker mainly used in the treatment of hypertension. It was the first successful beta blocker developed. Due to its nonselective and other pharmacokinetic problem, now a days it was not been the first line choice of drug. Various analogs of propranolol were synthesized to increase the duration of action and marketability. The new analogs (IV) were synthesized by reacting epichlorohydrine (I) with alpha naphthol (II) and then the product epoxy naphthol (III) was reacted with ethyl ester of various essential amino acids (V). The synthesized compounds were characterized by various spectral analyses.

引用

页码：359 / 362

页数：4

共 50 条

[31] Synthesis of proteogenic amino acid-based NAD analogs
Li, Qing
Liu, Wujun
Zhao, Zongbao K.
TETRAHEDRON LETTERS, 2021, 72
[32] TOTAL SYNTHESIS OF MYCOPHENOLIC ACID, SOME ANALOGS AND SOME BIOGENETIC INTERMEDIATES
CANONICA, L
RINDONE, B
SCOLASTICO, C
SANTANIELLO, E
TETRAHEDRON, 1972, 28 (16) : 4395 - +
[33] ESSENTIAL AMINO ACID COMPOSITION OF SOME COMMON INDIAN PULSES
VIJAYARAGHAVAN, PK
SRINIVASAN, PR
JOURNAL OF NUTRITION, 1953, 51 (02): : 261 - 271
[34] A CONVENIENT SYNTHESIS OF THE NEUROEXCITATORY AMINO-ACID QUISQUALIC ACID AND ITS ANALOGS
BYCROFT, BW
CHHABRA, SR
GROUT, RJ
CROWLEY, PJ
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1984, (17) : 1156 - 1157
[35] SYNTHESIS OF SOME AMINO ACID THIOL ESTERS
RAY, RA
JOHNSTON, RB
JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (02) : 275 - &
[36] SYNTHESIS OF SOME AMINO ACID DERIVATIVES OF STYRENE
MORRIS, LR
MOCK, RA
MARSHALL, CA
HOWE, JH
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1959, 81 (02) : 377 - 382
[37] THE DESIGN AND SYNTHESIS OF BONE ACTIVE PHOSPHINIC ACID ANALOGS
EBETINO, FH
JAMIESON, LA
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1990, 200 : 11 - ACSC
[38] Nucleic acid components and their analogs: Design and synthesis of novel cytosine thioglycoside analogs
Elgemeie, Galal H.
Salah, Ali M.
Abbas, Nermeen S.
Hussein, Hoda A.
Mohamed, Reham A.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2017, 36 (02): : 139 - 150
[39] Encyclopedia of amino acid analogs
不详
CHIMICA OGGI-CHEMISTRY TODAY, 2002, 20 (7-8) : 17 - 17
[40] Fluorescent amino acid analogs
Twine, SM
Szabo, AG
BIOPHOTONICS, PT A, 2003, 360 : 104 - 127

← 1 2 3 4 5 →