Design and synthesis some analogs of propranolol using essential amino acid

Propranolol is a non-selective beta blocker mainly used in the treatment of hypertension. It was the first successful beta blocker developed. Due to its nonselective and other pharmacokinetic problem, now a days it was not been the first line choice of drug. Various analogs of propranolol were synthesized to increase the duration of action and marketability. The new analogs (IV) were synthesized by reacting epichlorohydrine (I) with alpha naphthol (II) and then the product epoxy naphthol (III) was reacted with ethyl ester of various essential amino acids (V). The synthesized compounds were characterized by various spectral analyses.