SUSTAINED-RELEASE NIFEDIPINE FORMULATIONS - MOMENT, MODELING AND SIMULATION AS PHARMACOKINETIC ANALYSIS APPROACH

被引：6
|
作者：
REMUNAN, C
MRHAR, A
PRIMOZIC, S
KARBA, R
VILAJATO, JL
机构：
[1] EDVARD KARDELJ UNIV, FAC NAT SCI & TECHNOL, DEPT PHARM, YU-61000 LJUBLJANA, SLOVENIA
[2] EDVARD KARDELJ UNIV, FAC ELECT & COMP ENGN, YU-61000 LJUBLJANA, SLOVENIA
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 02期
关键词：
D O I：
10.3109/03639049209043693
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The bioequivalence of three sustained release nifedipine formulations designed in this laboratory, was assayed in rabbits by comparing their plasma time profiles to a reference (Adalat(R) retard). The analysis of data was performed by using the statistical moments as a measure of drug release. Results show a slowler absorption rate in the experimental formulations than in Adalat(R) retard, and not differences in the absorption extent. The composed one-compartment model, described for humans, showed to be also succesfull for rabbits.
引用
收藏
页码：187 / 202
页数：16
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