DIRECTED SYNTHESIS OF PEPTIDES FROM ALPHA-AMINO-ACID ESTERS AT METAL CENTERS

被引：43
|
作者：
BECK, W
KRAMER, R
机构：
[1] Institut Für Anorganische Chemie, Universität München, W-8000
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 11期
关键词：
D O I：
10.1002/anie.199114671
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Peptide esters coordinated in a chelate fashion as in 1 (M = Rh, R = Me) may be extended on the amino ends by reaction with alpha-amino acid esters in the presence of base. In the case of L-leucine methyl ester the resulting tripeptide ester can be cleaved from the metal center with virtually no racemization. The organometallic reagent [{(C5Me5)RhCl2}2] can be recovered.
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页码：1467 / 1469
页数：3
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