CHANGES IN NUMBER OF A-ADRENERGIC RECEPTOR SUBTYPES IN HEPATOCYTES FROM RATS FED 3'-METHYL-4-DIMETHYLAMINOAZOBENZENE

被引：3
|
作者：
MIYAMOTO, K
SANAE, F
KOHEI, K
NOMURA, M
KOSHIURA, R
机构：
[1] Division of the Research Laboratory, Development of Medicine, School of Pharmacy, Hokuriku University, Kanagawa, 920-11
来源：
JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 6-7期
关键词：
3′‐Methyl‐4‐dimethylaminoazobenzene; Hepatocyte; α [!sub]1[!/sub]‐Adrenergic receptor; α [!sub]2[!/sub]‐Adrenergic receptor;
D O I：
10.1111/j.1349-7006.1990.tb02607.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Changes in numbers of α1‐ and α2‐adrenergic receptors in the plasma membranes of hepatocytes from female Donryu rats given feed containing 0.06% of the carcinogen 3′‐methyl‐4‐dimethylamino‐azobenzene (3′‐MeDAB), were examined. α1‐Adrenergic receptors, measured in terms of [3H]‐prazosin binding, decreased to half of the control 2 weeks after the start of this diet, then gradually decreased for the next 22 weeks. α2‐Adrenergic receptors, measured in terms of [3H]clonidine binding, transiently increased 3‐fold over the control at 2 weeks. These changes in the early period of the 3′‐MeDAB diet intake may be related to hepatocarcinogenesis. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码：557 / 559
页数：3
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