TREATMENT WITH ASSOCIATED SODIUM-BUTYRATE AND IL-2 AGAINST RAT PERITONEAL CARCINOMATOSIS INDUCED BY A COLON-CARCINOMA CELL-LINE

被引：0
|
作者：
PERRIN, P
BURG, C
VAVASSEUR, F
GALMICHE, JP
BORNET, F
MEFLAH, K
机构：
[1] DEPT NUTR & SANTE,GRP ERIDANIA BEGHIN SAY,F-75008 PARIS,FRANCE
[2] CHU NORD,FONCT DIGEST & NUTR LAB,F-44035 NANTES 01,FRANCE
来源：
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES | 1993年 / 316卷 / 06期
关键词：
COLON CANCER; IMMUNOTHERAPY; INTERLEUKIN-2; SODIUM BUTYRATE; PERITONEAL CARCINOMATOSIS;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Two therapeutic assays associating sodium butyrate (NaB) and interleukin-2 (IL-2) were applied on rats after intraperitoneal (i.p.) injection of colon carcinoma cells. The first assay began at day 1 after cell injection, and the second one at day 10 after injection, i. e. when carcinomatosis was established. IL-2 was given i.p. three times per day and NaB one time per day, for five and seven days respectively. The survival median of IL-2 treated rats significantly increased versus those of untreated ones, and was much higher with NaB in supplement. Moreover, using this associative treatment, we observed some cases of complete curacy, even in rats bearing established carcinomatosis.
引用
收藏
页码：611 / 614
页数：4
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