SYNTHESIS OF DEUTERIUM-LABELED (11S,12R)[H-2(14)]-PALMITIC ACIDS AND (11R,12S)-[H-2(14)]-PALMITIC ACIDS - A FACILE ROUTE TO HIGHLY LABELED FATTY-ACIDS

被引：10

作者：

FROSSL, C ^{[1
]}

BOLAND, W ^{[1
]}

机构：

[1] UNIV KARLSRUHE,INST ORGAN CHEM,RICHARD WILLSTATTER ALLEE 2,D-76131 KARLSRUHE 1,GERMANY

来源：

TETRAHEDRON | 1993年 / 49卷 / 30期

关键词：

D O I：

10.1016/S0040-4020(01)81830-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral, highly deuterated palmitic acids are synthesised from 2,2'-bithienyl in three steps by two alkylations and reductive desulfurisation for the introduction of twelve deuterium atoms. The chiral building blocks are obtained from a,beta-unsaturated acids by enantiospecific reduction with broken cells of the microorganism Clostridium tyrobutyricum.

引用

页码：6613 / 6618

页数：6

共 35 条

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[32] STRUCTURE OF A COMPLEX BETWEEN REL-(6R,11S,17R,22S)-6,7,8,9,10,11,17,18,19,20,21,22-DODECAHYDRO-1,5,12,16,23,26,29-HEPTAOXA[73,14][5.5]ORTHOCYCLOPHANE AND MAGNESIUM BIS(PERCHLORATE) MONOHYDRATE, C22H38O7.MG(CLO4)2.H2O
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[33] STUDIES ON OPTICALLY ACTIVE AMINO ACIDS .16. STUDIES ON ALPHA-ALKYL-ALPHA-AMINO ACIDS .11. SYNTHESIS OF R-ALPHA-METHYLPHENYLALANINE FROM S(+)-2-METHYL-3-PHENYLPROPIONIC ACID BY DIRECT CONVERSION OF OPTICALLY ACTIVE C-H BOND INTO C-N BOND
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[34] Crystal structure of (S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-N-methoxy-N-methylpropanamide (Fernholz Weinreb amide)
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ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2015, 71 : 275 - +
[35] (10S,13R,14R)-17-(2-Hydroxy-1,5-dimethylhex-4-enyl)-4,4,10,13,14-pentamethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
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ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O733 - O734

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