EDITING OF A TRANSFER-RNA ANTICODON IN MARSUPIAL MITOCHONDRIA CHANGES ITS CODON RECOGNITION

被引：116

作者：

JANKE, A ^{[1
]}

PAABO, S ^{[1
]}

机构：

[1] UNIV MUNICH,INST ZOOL,LUISENSTR 14,W-8000 MUNICH 2,GERMANY

来源：

NUCLEIC ACIDS RESEARCH | 1993年 / 21卷 / 07期

关键词：

D O I：

10.1093/nar/21.7.1523

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA editing has been described for organellar genes of protozoa and plants as well as in three cases for nuclear transcipts of mammals. The mitochondrial tRNA for aspartic acid is encoded in the mitochondrial genome of marsupials with the anticodon GCC. However, cDNA from the gene product revealed that the second nucleotide of the anticodon of the tRNA is posttranscriptionally changed to be recognized as an uridine residue. This restores the coding property of the tRNA. Direct sequencing as well as clones of the amplified cDNA indicated that about 50% of the cellular pool of pre-tRNA molecules for aspartic acid is edited. Thus, RNA editing occurs in mammalian mitochondria and can affect the anticodons of tRNAs.

引用

页码：1523 / 1525

页数：3

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