BETA-2-MICROGLOBULIN DEFICIENT MICE LACK CD4-8+ CYTOLYTIC T-CELLS

被引：961
|
作者：
ZIJLSTRA, M
BIX, M
SIMISTER, NE
LORING, JM
RAULET, DH
JAENISCH, R
机构：
[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02142
[2] MIT,CTR CANC RES,CAMBRIDGE,MA 02142
来源：
NATURE | 1990年 / 344卷 / 6268期
关键词：
D O I：
10.1038/344742a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Mice homozygous for a β2-microglobulin gene disruption do not express any detectable β2-ITL protein. They express little if any functional major histocompatibility complex (MHC) class I antigen on the cell surface yet are fertile and apparently healthy. They show a normal distribution of γδ, CD4+8+ and CD4+8- cells, but have no mature CD4-8+ cells and are defective in CD4-8+ cell-mediated cytotoxicity. Our results strongly support earlier evidence that MHC class I molecules are crucial for positive selection of T cell antigen receptor αβ+ CD4-8+ T cells in the thymus and call into question the non-immune functions that have been ascribed to MHC class I molecules. © 1990 Nature Publishing Group.
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页码：742 / 746
页数：5
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