LOCALIZATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) TO A GENE-CLUSTER ON CHROMOSOME 17Q

被引：4
|
作者：
LEWIS, TB
SAENZ, M
OCONNELL, P
LEACH, RJ
机构：
[1] UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,SAN ANTONIO,TX 78284
[2] UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,SAN ANTONIO,TX 78284
来源：
GENOMICS | 1994年 / 19卷 / 03期
关键词：
D O I：
10.1006/geno.1994.1114
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Glucose-dependent insulinotropic polypeptide (GIP) has been regionally localized to a gene cluster on human chromosome 17q. Genetic mapping through CEPH reference families demonstrated that GIP was tightly linked to NME1 and PPY and fully linked to HOXB6 and NGFR. High-resolution radiation hybrid mapping resolved the gene order as cen-PPY-HOXB6-NGFR-GIP-NME1-tel. GIP maps distal to NGFR with an estimated distance of 250 kb. (C) 1994 Academic Press, Inc.
引用
下载
收藏
页码：589 / 591
页数：3
相关论文
共 50 条
  • [21] Structural studies of glucose-dependent insulinotropic polypeptide (GIP) in micellular media
    Hewage, C. M.
    Alana, I.
    O'Harte, F. P. M.
    DIABETOLOGIA, 2007, 50 : S245 - S246
  • [22] Plasticity of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in the vasculature
    Berglund, Lisa M.
    Kotova, Olga
    Goncalves, Isabel
    Kieffer, Timothy J.
    Lyssenko, Valeriya
    Groop, Leif
    Gomez, Maria F.
    FASEB JOURNAL, 2011, 25
  • [23] Effects of glucose-dependent insulinotropic polypeptide (GIP) on acid secretion in the rat
    Wolfe, MM
    Zhao, KB
    Jarboe, LA
    Tseng, CC
    GASTROENTEROLOGY, 1999, 116 (04) : A356 - A356
  • [24] The role of glucose-dependent insulinotropic polypeptide (gip) in adipocyte development and signaling
    Song, DH
    Tseng, E
    Simon, JT
    Wolfe, MM
    GASTROENTEROLOGY, 2005, 128 (04) : A9 - A9
  • [25] Glucose-dependent insulinotropic polypeptide (GIP) promotes triglyceride synthesis in adipocytes
    Wolfe, MM
    Getty, L
    Boylan, MO
    Corkey, BE
    GASTROENTEROLOGY, 2003, 124 (04) : A30 - A30
  • [26] A Reappraisal of Antagonists for the Human Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor
    Christensen, Mikkel
    Hansen, Laerke S.
    Rosenkilde, Mette M.
    Holst, Jens J.
    Knop, Filip K.
    DIABETES, 2012, 61 : A482 - A482
  • [27] Glucose-dependent insulinotropic polypeptide (GIP) and the enteroinsular axis in equines (Equus caballus)
    Dühlmeier, R
    Deegen, E
    Fuhrmann, H
    Widdel, A
    Sallmann, HP
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 2001, 129 (2-3): : 563 - 575
  • [28] INCREASED GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) IS ASSOCCIATED WITH INFLAMMATION IN OBESE SUBJECTS
    Malczewska-Malec, M.
    Malczewska-Malec, M.
    Polus, A.
    Goralska, J.
    Razny, U.
    Dembinska-Kiec, A.
    Solnica, B.
    ATHEROSCLEROSIS, 2016, 252 : E177 - E177
  • [29] Stimulation of Pancreatic Cancer Cell Growth By Glucose-Dependent Insulinotropic Polypeptide (GIP)
    Feuerstein, Joseph D.
    Prabakaran, Daniel
    Ku, Jennifer
    Bijpuria, Priti
    Wolfe, M. Michael
    GASTROENTEROLOGY, 2009, 136 (05) : A227 - A227
  • [30] Structural studies of the glucose-dependent insulinotropic polypeptide (GIP) by NMR and molecular modeling
    Hewage, CM
    Alaña, I
    O'Harte, FP
    Malthouse, JP
    FEBS JOURNAL, 2005, 272 : 373 - 373
12345