LOCALIZATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) TO A GENE-CLUSTER ON CHROMOSOME 17Q

被引：4
|
作者：
LEWIS, TB
SAENZ, M
OCONNELL, P
LEACH, RJ
机构：
[1] UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,SAN ANTONIO,TX 78284
[2] UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,SAN ANTONIO,TX 78284
来源：
GENOMICS | 1994年 / 19卷 / 03期
关键词：
D O I：
10.1006/geno.1994.1114
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Glucose-dependent insulinotropic polypeptide (GIP) has been regionally localized to a gene cluster on human chromosome 17q. Genetic mapping through CEPH reference families demonstrated that GIP was tightly linked to NME1 and PPY and fully linked to HOXB6 and NGFR. High-resolution radiation hybrid mapping resolved the gene order as cen-PPY-HOXB6-NGFR-GIP-NME1-tel. GIP maps distal to NGFR with an estimated distance of 250 kb. (C) 1994 Academic Press, Inc.
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页码：589 / 591
页数：3
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