TRICYCLIC COMPOUNDS AS SELECTIVE MUSCARINIC RECEPTOR ANTAGONISTS .3. STRUCTURE SELECTIVITY RELATIONSHIPS IN A SERIES OF CARDIOSELECTIVE (M2) ANTIMUSCARINICS

被引：47
|
作者：
ENGEL, WW
EBERLEIN, WG
MIHM, G
HAMMER, R
TRUMMLITZ, G
机构：
[1] DR KARL THOMAE GMBH,DEPT CHEM RES,D-7950 BIBERACH RISS,FED REP GER
[2] IST ANGELI SPA,DEPT BIOCHEM,MILAN,ITALY
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 08期
关键词：
D O I：
10.1021/jm00128a008
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：1718 / 1724
页数：7
相关论文
共 50 条
  • [41] M2 AND M3 MUSCARINIC RECEPTOR EXPRESSION IN BLADDER TUMOR
    Asutay, Mehmet Kazim
    Aydin, Banu
    Toper, Hasan
    Filinte, Deniz
    Cabadak, Hulya
    Tinay, Ilker
    JOURNAL OF UROLOGY, 2018, 199 (04): : E778 - E778
  • [42] Muscarinic M1 receptor agonists and M2 receptor antagonists as therapeutic targets in Alzheimer's disease
    Sheardown, MJ
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2002, 12 (06) : 863 - 870
  • [43] ASSESSMENT OF SELECTIVITY OF MUSCARINIC ANTAGONISTS FOR M1 AND M2 RECEPTORS IN RABBIT ISOLATED VAS-DEFERENS
    ELTZE, M
    PHARMACOLOGY, 1988, 37 : 40 - 47
  • [44] MUSCARINIC RECEPTOR HETEROGENEITY IN RAT CENTRAL-NERVOUS-SYSTEM .1. BINDING OF 4 SELECTIVE ANTAGONISTS TO 3 MUSCARINIC RECEPTOR SUBCLASSES - A COMPARISON WITH M2 CARDIAC MUSCARINIC RECEPTORS OF THE C-TYPE
    WAELBROECK, M
    GILLARD, M
    ROBBERECHT, P
    CHRISTOPHE, J
    MOLECULAR PHARMACOLOGY, 1987, 32 (01) : 91 - 99
  • [45] J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors
    Mitsuya, M
    Mase, T
    Tsuchiya, Y
    Kawakami, K
    Hattori, H
    Kobayashi, K
    Ogino, Y
    Fujikawa, T
    Satoh, A
    Fujikawa, T
    Satoh, A
    Kimura, T
    Noguchi, K
    Ohtake, N
    Tomimoto, K
    BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (11) : 2555 - 2567
  • [46] Piperidino piperidine M2 muscarinic receptor antagonists for the treatment of Alzheimer's disease.
    Boyle, CD
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U233 - U233
  • [47] FACILITATION OF AMPHETAMINE-INDUCED ROTATION BY MUSCARINIC ANTAGONISTS IS CORRELATED WITH M2 RECEPTOR AFFINITY
    HAGAN, JJ
    TONNAER, JADM
    RIJK, H
    BROEKKAMP, CLE
    VANDELFT, AML
    BRAIN RESEARCH, 1987, 410 (01) : 69 - 73
  • [48] FACILITATION OF AMPHETAMINE-INDUCED ROTATION BY MUSCARINIC ANTAGONISTS IS CORRELATED WITH M2 RECEPTOR AFFINITY
    HAGAN, JJ
    TONNAER, JADM
    RIJK, H
    BROEKKAMP, CLE
    VANDELFT, AML
    PSYCHOPHARMACOLOGY, 1986, 89 (04) : S18 - S18
  • [49] STRUCTURE-ACTIVITY-RELATIONSHIPS IN THE SERIES OF MUSCARINIC ANTAGONISTS - 4 MODES OF ANTAGONIST-RECEPTOR BINDING
    TROPSHA, AE
    NIZHNY, SV
    YAGUZHINSKY, LS
    BIOORGANICHESKAYA KHIMIYA, 1985, 11 (10): : 1402 - 1416
  • [50] Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor
    Suno, Ryoji
    Lee, Sangbae
    Maeda, Shoji
    Yasuda, Satoshi
    Yamashita, Keitaro
    Hirata, Kunio
    Horita, Shoichiro
    Tawaramoto, Maki S.
    Tsujimoto, Hirokazu
    Murata, Takeshi
    Kinoshita, Masahiro
    Yamamoto, Masaki
    Kobilka, Brian K.
    Vaidehi, Nagarajan
    Iwata, So
    Kobayashi, Takuya
    NATURE CHEMICAL BIOLOGY, 2018, 14 (12) : 1150 - +
12345