Near-Infrared Bodipy-Based Molecular Rotors for.. -Amyloid Imaging In Vivo

被引:0
|
作者
Ma, Lijun [1 ]
Geng, Yujie [1 ]
Zhang, Guoyang [1 ]
Hu, Ziwei [1 ]
James, Tony D. [2 ,3 ]
Wang, Xuefei [4 ]
Wang, Zhuo [1 ,2 ]
机构
[1] Beijing Univ Chem Technol, Coll Chem, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
[2] Univ Bath, Dept Chem, Bath BA2 7AY, England
[3] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China
[4] Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China
基金
北京市自然科学基金;
关键词
beta amyloid; biological imaging; central nervous system; fluorescent probes; rodent models;
D O I
暂无
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
beta -amyloid (A.beta) is one of the important biomarkers for diagnosing Alzheimer's disease (AD). Many near-infrared probes based on the donor-.Pi -acceptor structure have been developed to detect A.beta Most reported A.beta probes are based on the N,N-dimethylamino group as the ideal donor, which is a widely accepted binding unit. As such, the development of fluorescent probes with improved binding units to detect A beta. is urgently required. Therefore, with this research three anchoring molecular rotor electron donors consisting of cyclic amines of different ring sizes are developed, namely five-membered ring (TPyr), six-membered ring (TPip), and seven-membered ring (THAI). These new anchored molecular rotors are connected to a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) and named TPyrBDP, TPipBDP, and THAIBDP. These probes exhibit high affinities (from 28 to 54 nm) for A.beta (1-42) aggregates. The six-membered ring dye TPipBDP exhibits the highest signal-to-noise (75.5-fold) and higher affinity (28.30 +/- 5.94 nm). TPipBDP can cross the blood-brain barrier and exhibits higher fluorescence enhancement with APP/PS1 (AD) double transgenic (Tg) mice than with wild-type (WT) mice.
引用
收藏
页数:11
相关论文
共 50 条
  • [31] Dual-Responsive Near-Infrared BODIPY-Based Fluorescent Probe for the Detection of F- and HClO in Organisms
    Mei, Yuan
    Hai, Zijuan
    Li, Ziyun
    Rong, Kuanrong
    Tang, Wenjian
    Song, Qin-Hua
    ANALYTICAL CHEMISTRY, 2024, 96 (09) : 3802 - 3809
  • [32] A BODIPY-based near infrared fluorescent probe for Fe3+ in water
    Ji, Jiecheng
    Chereddy, Syama Sundar
    Ren, Yi
    Chen, Xingming
    Su, Dan
    Zhong, Zhihui
    Mori, Tadashi
    Inoue, Yoshihisa
    Wu, Wanhua
    Yang, Cheng
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2018, 355 : 78 - 83
  • [33] Monitoring membrane viscosity in differentiating stem cells using BODIPY-based molecular rotors and FLIM
    Kashirina, Alena S.
    Lopez-Duarte, Ismael
    Kubankova, Marketa
    Gulin, Alexander A.
    Dudenkova, Varvara V.
    Rodimova, Svetlana A.
    Torgomyan, Hayk G.
    Zagaynova, Elena V.
    Meleshina, Aleksandra V.
    Kuimova, Marina K.
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [34] Monitoring membrane viscosity in differentiating stem cells using BODIPY-based molecular rotors and FLIM
    Alena S. Kashirina
    Ismael López-Duarte
    Markéta Kubánková
    Alexander A. Gulin
    Varvara V. Dudenkova
    Svetlana A. Rodimova
    Hayk G. Torgomyan
    Elena V. Zagaynova
    Aleksandra V. Meleshina
    Marina K. Kuimova
    Scientific Reports, 10
  • [35] Near-infrared BODIPY-based two-photon ClO- probe based on thiosemicarbazide desulfurization reaction: naked-eye detection and mitochondrial imaging
    Shen, Bao-xing
    Qian, Ying
    Qi, Zheng-qing
    Lu, Chang-gui
    Sun, Qi
    Xia, Xiang
    Cui, Yi-ping
    JOURNAL OF MATERIALS CHEMISTRY B, 2017, 5 (29) : 5854 - 5861
  • [36] Naphthalene-fused BODIPY near-infrared dye as a stable contrast agent for in vivo photoacoustic imaging
    Ni, Yong
    Kannadorai, Ravi K.
    Peng, Juanjuan
    Yu, Sidney W. -K.
    Chang, Young-Tae
    Wu, Jishan
    CHEMICAL COMMUNICATIONS, 2016, 52 (77) : 11504 - 11507
  • [37] Deep learning for in vivo near-infrared imaging
    Ma, Zhuoran
    Wang, Feifei
    Wang, Weizhi
    Zhong, Yeteng
    Dai, Hongjie
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (01)
  • [38] Two birds with one stone: A highly sensitive near-infrared BODIPY-based fluorescent probe for the simultaneous detection of Fe2+ and H+ in vivo
    Xu, Weijia
    Wu, Peng
    Li, Xiaoxin
    Liu, Senyao
    Feng, Liya
    Xiong, Hu
    TALANTA, 2021, 233
  • [39] Rational Design of Ratiometric Near-Infrared Aza-BODIPY-Based Fluorescent Probe for in Vivo Imaging of Endogenous Hydrogen Peroxide
    Mao, Wenle
    Zhu, Mingming
    Yan, Chenxu
    Ma, Yiyu
    Guo, Zhiqian
    Zhu, Weihong
    ACS APPLIED BIO MATERIALS, 2020, 3 (01) : 45 - 52
  • [40] Near-infrared fluorescent BODIPY dyes: Green synthesis, photophysical properties, and their applications in biomedical molecular imaging
    Segovia-Perez, Raul
    Ibarra-Rodriguez, Marisol
    Munoz-Flores, Blanca M.
    Jimenez-Perez, Victor M.
    DYES AND PIGMENTS, 2025, 239