PROTEIN-KINASE C-ALPHA INHIBITORS - STRUCTURE-ACTIVITY-RELATIONSHIPS IN BIS-INDOLE SERIES

被引：9
|
作者：
XIE, GJ
ZIMMERMANN, J
MEYER, T
LOWN, JW
机构：
[1] UNIV ALBERTA,DEPT CHEM,EDMONTON,AB T6G 2G2,CANADA
[2] CIBA GEIGY AG,DIV PHARMACEUT,CH-4002 BASEL,SWITZERLAND
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 05期
关键词：
D O I：
10.1016/0960-894X(95)00060-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
To assess the role of the amine and ester containing oligopeptide side-chains in bis-indole protein kinase C inhibitors, six novel hybrids in this series were synthesized. These new compounds displayed effective inhibitory activity against protein kinase C-alpha.
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页码：497 / 500
页数：4
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