DOPAMINE-3'-5'-MONOPHOSPHATE AND ADENOSINE-3'-5'-MONOPHOSPHATE (CAMP)-REGULATED PHOSPHOPROTEIN OF MR 32,000 (DARPP-32) IN THE RETINA OF CAT, MONKEY AND HUMAN

The cellular localization of a dopamine- and cAMP-regulated phosphoprotein of M(r) 32,000 (DARPP-32) was investigated in cat, monkey and human retina by immunohistochemistry. In cat, DARPP-32-immunoreactive cell bodies identified as Muller cells were demonstrated in the inner nuclear layer (INL) with processes closely surrounding the cell soma of photoreceptors in the outer nuclear layer. Some DARPP-32-IR cells were also seen in the nerve fiber layer (NFL) sending processes to the inner plexiform layer. In monkey and human retina, DARPP-32-IR cell bodies were also demonstrated in the INL, with few cells located in the NFL.