ENANTIOSELECTIVE TOTAL SYNTHESES OF BENGAMIDE-B AND BENGAMIDE-E

被引：55
|
作者：
BROKA, CA
EHRLER, J
机构：
[1] Syntex Research, Institute of Bio-Organic Chemistry, Palo Alto, CA 94304
来源：
TETRAHEDRON LETTERS | 1991年 / 32卷 / 42期
关键词：
D O I：
10.1016/S0040-4039(00)79423-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Convergent total syntheses of two sponge-derived cyclolysine derivatives - bengamides B (1) and E (2) - have been accomplished. The polyhydroxylated side chain common to both natural products was obtained from L-glucose and the hydroxylated caprolactam moiety of 1 was prepared using Evans' oxazolidinone chemistry. In the course of this work a new Horner-Emmons reagent incorporating one of Evans' chiral auxiliaries was developed.
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页码：5907 / 5910
页数：4
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