SAFETY AND IMMUNOGENICITY OF AN INACTIVATED HEPATITIS-A CANDIDATE VACCINE IN HEALTHY ADULT VOLUNTEERS

被引：78
|
作者：
WIEDERMANN, G
AMBROSCH, F
KOLLARITSCH, H
HOFMANN, H
KUNZ, C
DHONDT, E
DELEM, A
ANDRE, FE
SAFARY, A
STEPHENNE, J
机构：
[1] UNIV VIENNA,INST VIROL,A-1010 VIENNA,AUSTRIA
[2] SMITH KLINE BIOL,RIXENSART,BELGIUM
来源：
VACCINE | 1990年 / 8卷 / 06期
关键词：
Candidate vaccine; ELISA; hepatitis A; inactivated;
D O I：
10.1016/0264-410X(90)90013-C
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The reactogenicity and immunogenicity of a formaldehyde-inactivated hepatitis A vaccine have been investigated. Three different dose levels of vaccine (180, 360 and 720 ELISA units) were administered to healthy volunteers according to a 0, 1, 2 and 12 month schedule. The vaccine was safe and well tolerated. Reactions observed following vaccination were essentially mild and were not dependent upon the quantity of antigen administered. All subjects had measurable titres of anti-HAV antibodies after the full vaccination course; the immune response to the vaccine was dose-related. Antibody titres in vaccinees at month 13 were between 60- and 190-fold higher than those observed in a group of subjects given anti-HAV immunoglobulin. © 1990.
引用
收藏
页码：581 / 584
页数：4
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