SIGNAL-TRANSDUCTION AND CELL FATE SPECIFICATION DURING CAENORHABDITIS-ELEGANS VULVAR DEVELOPMENT

被引：47
|
作者：
EISENMANN, DM
KIM, SK
机构：
[1] Department of Developmental Biology, Beckman Center B300, Stanford University Medical Center, Stanford
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 04期
关键词：
D O I：
10.1016/0959-437X(94)90065-B
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A receptor tyrosine kinase/Ras signaling pathway controls the specification of vulval cell fates in Caenorhabditis elegans. Recently, C. elegans genes encoding proteins with similarity to mammalian Raf (lin-45), mitogen-activated protein kinase (mpk-1/sur-1), and an HNF-3 transcription factor (lin-31) have been identified and shown to act downstream of let-60 (ras) in this pathway. These genetically identified gene products bridge the gap between signal transduction at the plasma membrane and the control of cell fate specification in the nucleus.
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页码：508 / 516
页数：9
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