Imidacloprid inhibits IgE-mediated RBL-2H3 cell degranulation and passive cutaneous anaphylaxis

被引：9

作者：

Shi, Linbo ^{[1
]}

Zou, Li ^{[1
,2
]}

Gao, Jinyan

Xu, Huaing ^{[3
]}

Shi, Xiaoyun ^{[4
]}

Chen, Hongbing ^{[1
]}

机构：

[1] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China

[2] Nanchang Univ, Sch Food Sci, Nanchang 330047, Jiangxi, Peoples R China

[3] Nanchang Univ, Dept Rehabil, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China

[4] Nanchang Univ, Dept Anesthesiol, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China

来源：

ASIA PACIFIC ALLERGY | 2016年 / 6卷 / 04期

基金：

国家高技术研究发展计划(863计划);

关键词：

Imidacloprid; Mast cells; Ca2+ influx;

D O I：

10.5415/apallergy.2016.6.4.236

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Imidacloprid has been commonly used as a pesticide for crop protection and acts as nicotinic acetylcholine receptor agonists. Little information about the relationship between imidacloprid and allergy is available. Objective: This study aims to examine the effects of imidacoprid on IgE-mediated mast cell activation. Methods: The rat basophilic leukemia cell line RBL-2H3 (RBL-2H3 cells) were treated with 10(-3)-10(-12) mol/L imidacloprid, followed by measuring the mediator production, influx of Ca2+ in IgE-activated RBL-2H3 cells, and the possible effects of imidacoprid on antidinitrophenyl IgE-induced passive cutaneous anaphylaxis (PCA). Results: It was shown that imidacoprid suppressed the production of histamine, beta-hexosaminidase, leukotriene C4, interleukin-6, tumor necrosis factor-alpha, and Ca2+ mobilization in IgE-activated RBL-2H3 cells and decreased vascular extravasation in IgE-induced PCA. Conclusion: It is the first time to show that imidacloprid suppressed the activation of RBL-2H3 cells.

引用

页码：236 / 244

页数：9

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