BETA(2)-GPI-DEPENDENT AND INDEPENDENT BINDING OF ANTICARDIOLIPIN ANTIBODIES IN PATIENTS WITH RECURRENT SPONTANEOUS-ABORTIONS

被引：12
|
作者：
OZAWA, N [1 ]
MAKINO, T [1 ]
MATSUBAYASHI, H [1 ]
HOSOKAWA, T [1 ]
SOMEYA, K [1 ]
NOZAWA, S [1 ]
MATSUURA, E [1 ]
机构：
[1] YAMASA CORP, IMMUNOL LAB, DIV DIAGNOST, CHOSHI, CHIBA, JAPAN
来源：
JOURNAL OF CLINICAL LABORATORY ANALYSIS | 1994年 / 8卷 / 05期
关键词：
COFACTOR; ANTIPHOSPHOLIPID SYNDROME; THROMBOSIS; HABITUAL ABORTION; SLE (SYSTEMIC LUPUS ERYTHEMATOSUS);
D O I：
10.1002/jcla.1860080502
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
We measured anticardiolipin antibodies (aCL) in plasma samples from 214 women with a history of recurrent spontaneous abortions by an enzyme-linked immunosorbent assay (ELISA) utilizing solid phase cardiolipin (CL) and beta(2)-glycoprotein I (beta(2)-GPI). Sixteen patients (7.5%) were positive for beta(2)-GPI-dependent aCL. Though beta(2)-GPI appeared to enhance the binding of aCL, beta(2)-GPI-independent aCL were also observed in these patients (4.7%). The patients were classified into three groups on the basis of their medical history, and analysis of data of individual groups revealed that the incidence of beta(2)-GPI-dependent aCL was significantly higher in patients who had experienced at least one fetal loss in the second or third trimester. (C) 1994 Wiley-Liss, Inc.
引用
收藏
页码：255 / 259
页数：5
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