SUPPRESSION OF LIPOLYSIS IN NORMAL MAN DOES NOT INHIBIT RECOVERY FROM INSULIN-INDUCED HYPOGLYCEMIA

被引：3
|
作者：
NEWRICK, PG [1 ]
BRAATVEDT, G [1 ]
STANSBIE, D [1 ]
CORRALL, RJM [1 ]
机构：
[1] BRISTOL ROYAL INFIRM & GEN HOSP,DEPT CHEM PATHOL,BRISTOL BS2 8HW,AVON,ENGLAND
来源：
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1993年 / 23卷 / 01期
关键词：
ACIPIMOX; HYPOGLYCEMIC RECOVERY; LIPOLYSIS;
D O I：
10.1111/j.1365-2362.1993.tb00717.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pharmacological suppression of lipolysis is being increasingly used in the treatment of diabetic hyperlipidaemia. Although theoretical hazard of such treatment is that recovery from hypoglycaemia might be impaired. Seven normal subjects were therefore studied on two occasions, following treatment with a single dose of either acipimox 250 mg or placebo. Hypoglycaemic recovery was unaffected, despite effective suppression of plasma non-esterified fatty acid levels with acipimox. The results suggest that under these conditions activation of lipolysis may not be essential to recovery from hypoglycaemia.
引用
收藏
页码：53 / 56
页数：4
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