PRIMATE P53 INHIBITS SV40 DNA-REPLICATION INVITRO

被引：9
|
作者：
MIYAMOTO, N
KIHARA, E
INADA, T
KATSURA, S
MURAKAMI, Y
机构：
[1] UNIV TSUKUBA,INST BASIC MED SCI,DEPT RADIAT BIOL,TSUKUBA,JAPAN
[2] UNIV TOKYO,FAC ENGN,DEPT CHEM ENGN,TOKYO 113,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 02期
关键词：
D O I：
10.1016/0006-291X(90)92363-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Previous reports indicated that rodent p53 inhibits simian virus 40 (SV40) DNA replication in vitro as well as in vivo while that from primate cells does not (1-4). Here we report the evidence that p53 of primate origin also inhibits SV40 DNA replication in vitro. p53-SV40 large tumor antigen (T antigen) complex purified from SV40 infected COS-1 cells had little replication activity and inhibited SV40 DNA replication in vitro. These results suggest that inhibition of SV40 DNA replication by p53 should be regarded as general property of the protein and does not determine the mode of species specific replication of SV40 DNA. © 1990.
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页码：604 / 608
页数：5
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