MONOSODIUM URATE TEST - A NEW ANALGESIC TEST BY CRYSTAL-INDUCED MONOARTHRITIS IN RATS

被引：2
|
作者：
OTSUKI, T
AGATSUMA, Y
JOKURA, H
SAKURADA, S
KISARA, K
YOSHIMOTO, T
机构：
[1] TOHOKU COLL PHARMACEUT SCI,DEPT PHARMACOL,SENDAI 980,JAPAN
[2] TOHOKU UNIV,SCH MED,DEPT NEUROSURG,SENDAI,MIYAGI 980,JAPAN
来源：
JOURNAL OF NEUROSCIENCE METHODS | 1990年 / 33卷 / 2-3期
关键词：
Analgesic test; Animal model; Arthritis; Monosodium urate; Tonic pain;
D O I：
10.1016/0165-0270(90)90026-C
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The analgesic effects of various agents were evaluated in knee joint monoarthritic rats where arthritis was induced by monosodium urate (MSU) crystals injected into the knee joint cavities. The weight supported by each hind limb was measured quantitatively using pressure transducers, which revealed dose-dependent recovery produced by various analgesics including morphine but no changes in value by sedatives such as chlorpromazine. Relative potency obtained from the value of ED50 of each analgesic agent was congruent with that in clinical use. The MSU test may be quite suitable for quantitative and objective evaluation of the analgesic effects of various agents, particularly for spontaneous and tonic pain. © 1990.
引用
收藏
页码：229 / 231
页数：3
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