PRODUCTION OF NERVE GROWTH-FACTOR IN RAT SKELETAL-MUSCLE

被引：52

作者：

AMANO, T ^{[1
]}

YAMAKUNI, T ^{[1
]}

OKABE, N ^{[1
]}

SAKIMURA, K ^{[1
]}

TAKAHASHI, Y ^{[1
]}

机构：

[1] NIIGATA UNIV, SCH MED, BRAIN RES INST, NIIGATA 95021, JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 132卷 / 01期

关键词：

NERVE GROWTH FACTOR; SKELETAL MUSCLE; MESSENGER RNA;

D O I：

10.1016/0304-3940(91)90418-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Production of the nerve growth factor (NGF) was confirmed by Northern blot hybridization using a specific probe of synthetic cDNA. In normal rat skeletal muscle, this probe clearly showed a band equivalent to 1.3 kilobases (kb) of messenger RNA (mRNA) of NGF of male mouse submaxillary gland. By denervation, the density of the bands derived from muscles increased by a factor of more than 3 at 4 and 6 days later compared to the control. The synthesis of mRNA of NGF in muscle was also confirmed following tetrodotoxin (TTX) blockade of sciatic nerve without denervation.

引用

页码：5 / 7

页数：3

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