INVERSION-ASSOCIATED TRANSLOCATIONS IN ACUTE MYELOMONOCYTIC LEUKEMIA WITH EOSINOPHILIA

被引：12
|
作者：
BERGER, R
DERRE, J
LECONIAT, M
HEBERT, J
ROMANA, PS
JONVEAUX, P
机构：
[1] HOSP ST LOUIS,INSERM,U301,MONTREAL,PQ,CANADA
[2] HOSP ST LOUIS,CNTRS,SDI 1 5954 1,MONTREAL,PQ,CANADA
[3] HOSP ST LOUIS,CENT HEMATOL LAB,MONTREAL,PQ,CANADA
来源：
GENES CHROMOSOMES & CANCER | 1995年 / 12卷 / 01期
关键词：
D O I：
10.1002/gcc.2870120110
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cytogenetic studies of three acute myelomonocytic leukemias with bone marrow eosinophilia (M4EO) revealed chromosome 16 inversion associated with additional abnormalities. The inverted chromosome 16 was involved in two patients. Fluorescence in situ hybridization (FISH) experiments with a YAC probe detecting inv(16) showed that the translocation breakpoints involving chromosomes 16 did not implicate the inversion breakpoints. FISH can thus distinguish between true variant translocations and translocations with other breakpoints on chromosome 16 in M4EO. (C) 1995 Wiley-Liss, Inc.
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页码：58 / 62
页数：5
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