REDUCTION IN THE CONTRACTION AND INTRACELLULAR CALCIUM TRANSIENT OF SINGLE-RAT VENTRICULAR MYOCYTES BY GADOLINIUM AND THE ATTENUATION OF THESE EFFECTS BY EXTRACELLULAR NAH2PO4

被引：20

作者：

WARD, H ^{[1
]}

WHITE, E ^{[1
]}

机构：

[1] UNIV LEEDS,DEPT PHYSIOL,LEEDS LS2 9JT,ENGLAND

来源：

EXPERIMENTAL PHYSIOLOGY | 1994年 / 79卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1113/expphysiol.1994.sp003737

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Gadolinium (Gd3+) is the most commonly used blocker of stretch-activated channels (SACs). The actions of Gd3+ in unstretched adult heart were investigated by observing its effects on the contraction and intracellular calcium transient of single rat ventricular myocytes. We found that Gd3+ caused a profound reduction in both these parameters at doses typically used to block SACs. However, the actions of Gd3+ were severely attenuated by the presence of 0.33 mM NaH2PO4, which possibly chelates the Gd3+ ion.

引用

页码：107 / 110

页数：4

共 22 条

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