ENZYME-CATALYZED ASYMMETRIC-SYNTHESIS - KINETIC RESOLUTION OF CHIRAL HYDROPEROXIDES BY ENANTIOSELECTIVE REDUCTION TO ALCOHOLS WITH HORSERADISH-PEROXIDASE

被引：0

作者：

ADAM, W ^{[1
]}

HOCH, U ^{[1
]}

SAHAMOLLER, CR ^{[1
]}

SCHREIER, P ^{[1
]}

机构：

[1] UNIV WURZBURG,INST PHARM & LEBENSMITTELCHEM,WURZBURG,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 12期

关键词：

D O I：

10.1002/anie.199317371

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly selective for (R)‐hydroperoxides (R)‐1, horseradish peroxidase (HRP) is used for the kinetic resolution of racemic 1 furnishing (R)‐2 alcohols and enantiomerically pure hydroperoxides, which are difficult to prepare by nonenzymatic means. This transformation carried out in the presence of guaiacol [Eq. (a)] can be conducted on a preparative scale. R1  Ph, C(CH2)CO2Me; R2  Me, Et. (Figure Presented.) Copyright © 1993 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1737 / 1739

页数：3

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