ENZYME-CATALYZED ASYMMETRIC-SYNTHESIS - KINETIC RESOLUTION OF CHIRAL HYDROPEROXIDES BY ENANTIOSELECTIVE REDUCTION TO ALCOHOLS WITH HORSERADISH-PEROXIDASE

被引：0
|
作者：
ADAM, W [1 ]
HOCH, U [1 ]
SAHAMOLLER, CR [1 ]
SCHREIER, P [1 ]
机构：
[1] UNIV WURZBURG,INST PHARM & LEBENSMITTELCHEM,WURZBURG,GERMANY
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 12期
关键词：
D O I：
10.1002/anie.199317371
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Highly selective for (R)‐hydroperoxides (R)‐1, horseradish peroxidase (HRP) is used for the kinetic resolution of racemic 1 furnishing (R)‐2 alcohols and enantiomerically pure hydroperoxides, which are difficult to prepare by nonenzymatic means. This transformation carried out in the presence of guaiacol [Eq. (a)] can be conducted on a preparative scale. R1  Ph, C(CH2)CO2Me; R2  Me, Et. (Figure Presented.) Copyright © 1993 by VCH Verlagsgesellschaft mbH, Germany
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页码：1737 / 1739
页数：3
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