S-(2-OXOPENTADECYL)-COA, A NONHYDROLYZABLE ANALOG OF MYRISTOYL-COA, IS A POTENT INHIBITOR OF MYRISTOYL-COA-PROTEIN N-MYRISTOYLTRANSFERASE

被引:45
|
作者
PAIGE, LA
ZHENG, GQ
DEFREES, SA
CASSADY, JM
GEAHLEN, RL
机构
[1] PURDUE UNIV,SCH PHARM & PHARMACEUT SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907
[2] OHIO STATE UNIV,COLL PHARM,COLUMBUS,OH 43210
关键词
D O I
10.1021/jm00128a001
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1665 / 1667
页数:3
相关论文
共 50 条
  • [41] Distribution of myristoyl-CoA:protein N-myristoyl transferase activity in rabbit intestine
    Magnuson, BA
    Raju, RVS
    Sharma, RK
    BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1996, 1300 (02): : 119 - 124
  • [42] PURIFICATION AND PARTIAL SEQUENCING OF BOVINE BRAIN MYRISTOYL-COA - PROTEIN N-MYRISTOYL TRANSFERASE
    MCILHINNEY, RAJ
    MCGLONE, K
    FASEB JOURNAL, 1993, 7 (07): : A1045 - A1045
  • [43] N-Myristoylation of Arf proteins in Candida albicans: An in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: Protein N-myristoyltransferase
    Lodge, JK
    JacksonMachelski, E
    Devadas, B
    Zupec, ME
    Getman, DP
    Kishore, N
    Freeman, SK
    McWherter, CA
    Sikorski, JA
    Gordon, JI
    MICROBIOLOGY-UK, 1997, 143 : 357 - 366
  • [44] 2-SUBSTITUTED DERIVATIVES OF MYRISTIC ACID ARE METABOLICALLY ACTIVATED TO FORM POTENT INHIBITORS OF MYRISTOYL COA - PROTEIN N-MYRISTOYLTRANSFERASE
    PAIGE, LA
    NADLER, MJ
    ZHENG, GQ
    DEFREES, SA
    CASSADY, JM
    GEAHLEN, RL
    FASEB JOURNAL, 1991, 5 (04): : A801 - A801
  • [45] Replacements for lysine in L-seryl-L-lysyl dipeptide amide inhibitors of Candida albicans myristoyl-CoA: Protein N-myristoyltransferase
    Brown, DL
    Devadas, B
    Lu, HF
    Nagarajan, S
    Zupec, ME
    Freeman, SK
    McWherter, CA
    Getman, DP
    Sikorski, JA
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (03) : 379 - 382
  • [46] KINETIC AND STRUCTURAL EVIDENCE FOR A SEQUENTIAL ORDERED BI BI MECHANISM OF CATALYSIS BY SACCHAROMYCES-CEREVISIAE MYRISTOYL-COA - PROTEIN N-MYRISTOYLTRANSFERASE
    RUDNICK, DA
    MCWHERTER, CA
    ROCQUE, WJ
    LENNON, PJ
    GETMAN, DP
    GORDON, JI
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1991, 266 (15) : 9732 - 9739
  • [47] MUTATIONS OF HUMAN MYRISTOYL-COA-PROTEIN N-MYRISTOYLTRANSFERASE CAUSE TEMPERATURE-SENSITIVE MYRISTIC ACID AUXOTROPHY IN SACCHAROMYCES-CEREVISIAE
    DURONIO, RJ
    REED, SI
    GORDON, JI
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (09) : 4129 - 4133
  • [48] N-MYRISTOYLATION OF P60SRC - IDENTIFICATION OF A MYRISTOYL-COA - GLYCYLPEPTIDE N-MYRISTOYLTRANSFERASE IN RAT-TISSUES
    GLOVER, CJ
    GODDARD, C
    FELSTED, RL
    BIOCHEMICAL JOURNAL, 1988, 250 (02) : 485 - 491
  • [49] THE CANDIDA-ALBICANS MYRISTOYL-COA-PROTEIN N-MYRISTOYLTRANSFERASE GENE - ISOLATION AND EXPRESSION IN SACCHAROMYCES-CEREVISIAE AND ESCHERICHIA-COLI
    WIEGAND, RC
    CARR, C
    MINNERLY, JC
    PAULEY, AM
    CARRON, CP
    LANGNER, CA
    DURONIO, RJ
    GORDON, JI
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1992, 267 (12) : 8591 - 8598
  • [50] A COMPARATIVE-ANALYSIS OF THE KINETIC MECHANISM AND PEPTIDE SUBSTRATE-SPECIFICITY OF HUMAN AND SACCHAROMYCES-CEREVISIAE MYRISTOYL-COA - PROTEIN N-MYRISTOYLTRANSFERASE
    ROCQUE, WJ
    MCWHERTER, CA
    WOOD, DC
    GORDON, JI
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1993, 268 (14) : 9964 - 9971