CORRELATION OF ANTIHYPERTENSIVE ACTIVITY WITH STRUCTURE IN A SERIES OF 2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDES USING SUBSTITUENT CONSTANT APPROACH

被引：49
|
作者：
TOPLISS, JG
YUDIS, MD
机构：
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1972年 / 15卷 / 04期
关键词：
D O I：
10.1021/jm00274a017
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：394 / &
相关论文
共 50 条
  • [21] 1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDES .3. REACTIONS OF 2-AMINOBENZENESULFONAMIDE WITH CHLOROALKYL ISOCYANATES
    CHERN, JW
    HO, CP
    WU, YH
    RONG, JG
    LIU, KC
    CHENG, MC
    WANG, Y
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1990, 27 (07) : 1909 - 1915
  • [22] SYNTHESIS OF 3-AMINO AND 3-SUBSTITUTED AMINO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDES
    PETERSEN, HJ
    ACTA CHEMICA SCANDINAVICA, 1973, 27 (07): : 2655 - 2660
  • [23] SYNTHESIS AND STRUCTURAL STUDIES OF A NEW CLASS OF HETEROCYCLIC-COMPOUNDS - 1,2,4-PYRIDOTHIADIAZINE 1,1-DIOXIDES, PYRIDYL ANALOGS OF 1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDES
    DETULLIO, P
    PIROTTE, B
    DUPONT, L
    MASEREEL, B
    LAECKMANN, D
    PODONA, T
    DIOUF, O
    LEBRUN, P
    DELARGE, J
    TETRAHEDRON, 1995, 51 (11) : 3221 - 3234
  • [24] Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides.: 8.: Synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential α1-adrenoceptor antagonists
    Chern, JW
    Tao, PL
    Wang, KC
    Gutcait, A
    Liu, SW
    Yen, MH
    Chien, SL
    Rong, JK
    JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (17) : 3128 - 3141
  • [25] A CONVENIENT SYNTHESIS OF 2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDES FROM 2-AMINOBENZENESULFONAMIDE AND CARBOXYLIC-ACIDS BY USING POLYPHOSPHORIC ACID TRIMETHYLSILYL ESTER AS CONDENSING AGENT
    IMAI, Y
    MOCHIZUKI, A
    KAKIMOTO, M
    SYNTHESIS-STUTTGART, 1983, (10): : 851 - 851
  • [26] Synthesis of pyrido-1,2,4-thiadiazines related to antihypertensive 1,2,4-benzothiadiazine-1,1-dioxides
    Neill, CG
    Preston, PN
    Wightman, RH
    TETRAHEDRON, 1998, 54 (44) : 13645 - 13654
  • [27] Impact of the Nature of the Substituent at the 3-Position of 4H-1,2,4-Benzothiadiazine 1,1-Dioxides on Their Opening Activity toward ATP-Sensitive Potassium Channels
    Pirotte, Bernard
    de Tullio, Pascal
    Boverie, Stephane
    Michaux, Catherine
    Lebrun, Philippe
    JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (09) : 3188 - 3199
  • [28] Facile Synthesis of 4H-1,2,4-Benzothiadiazine-1,1-dioxides
    Cherepakha, Artem
    Kovtunenko, Vladimir O.
    Tolmachev, Andrey
    Lukin, Oleg
    Nazarenko, Konstantin G.
    SYNTHETIC COMMUNICATIONS, 2011, 41 (13) : 1977 - 1989
  • [29] Palladium-Catalyzed Domino Reaction for the Synthesis of 3-Amino 1,2,4-Benzothiadiazine 1,1-Dioxides
    Hommelsheim, Rene
    van Nahl, Robin
    Hanek, Lena M.
    Ward, Jas S.
    Rissanen, Kari
    Bolm, Carsten
    ADVANCED SYNTHESIS & CATALYSIS, 2024, 366 (04) : 717 - 724
  • [30] Heterocyclization of N-(chlorosulfonyl)imidoyl chlorides with anilines, a new method of synthesis of 1,2,4-benzothiadiazine 1,1-dioxides
    Alexander A. Shalimov
    Tetyana I. Chudakova
    Yurii G. Vlasenko
    Anatoly D. Sinitsa
    Petro P. Onys’ko
    Chemistry of Heterocyclic Compounds, 2016, 52 : 267 - 274
12345